2014 Fiscal Year Final Research Report
Basic and clinical research about radiation-induced anti-tumor immunity
| Project/Area Number |
24591833
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
|
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| Research Institution | Fukushima Medical University (2014)
Gunma University (2012-2013) |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 放射線治療 / 腫瘍免疫 / HLA / HMGB1 / 免疫療法 |
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| Outline of Final Research Achievements |
I investigated about radiation-induced anti-tumor immunity in vitro and in vivo and reported about 1) The tumor antigen–specific T-cell response was induced by chemoradiotherapy in patients with esophageal squamous cell cancer, 2) Stress protein, HMGB1, released after irradiation played important role in the activation of tumor specific anti-tumor immunity, 3) In patients with rectal cancer, hyperthermo-chemo-radiotherapy enhaced the expression of HLA class-I in the tumor cells, and 4) In a mouse model, the immune response plays an important role in local and systemic therapeutic efficacies of radiotherapy, which can be augmented by immune checkpoint blockade (antiCTLA4 antibody etc.).
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| Free Research Field |
放射線腫瘍学
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