2015 Fiscal Year Final Research Report
Development of new radiotherapy targeting stem cell of glioblastoma
| Project/Area Number |
24591834
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| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
|
|---|
| Research Institution | Gunma University |
|---|
Principal Investigator |
NODA SHIN-EI 群馬大学, 医学部附属病院, 講師 (60396645)
|
|---|
| Project Period (FY) |
2012-04-01 – 2016-03-31
|
| Keywords | 神経膠芽腫 / GRP78 |
|---|
| Outline of Final Research Achievements |
cell cycle, DNA double strand break, intracell-metabolism, mechanism of radioresistance for GRP78 were verified using glioblastoma stem cell knockdowned GRP78 specifically by siRNA.
Radiosensitization of glioblastoma stem cell were measured by GRP78 knockdown in vivo.
|
| Free Research Field |
放射線腫瘍学
|
