Developement of a noble technique in external-beam radiation therapy

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591838
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kyoto University
• Principal Investigator: MIZOWAKI TAKASHI 京都大学, 医学(系)研究科(研究院), 准教授 (90314210)
• Co-Investigator(Kenkyū-buntansha): NORIHISA Yoshiki 京都大学, 大学院医学研究科, 助教 (90456898) ; INOKUCHI Haruo 京都大学, 大学院医学研究科, 助教 (60648880)
• Research Collaborator: IKEDA Itaru ; NAKAMURA Kiyonao ; YAMADA Masahiro
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 放射線治療 / 前立腺癌 / 寡分割照射 / 強度変調放射線治療 / 定位照射

Outline of Final Research Achievements

We performed a clinical study: "assessment of the intrafractional internal prostate motions during external beam radiation therapy (C594)". We found that baseline drift significantly affected on the actually delivered dose distribution, while respiration-induced movement had much smaller impacts. In addition, Adding a 7 mm margin is adequate to conpensate the effects of intrafractional movements, including baseline drifts, of the prostate. We also concluded that 54 Gy in 15 fractions is the most adequate schedule for hypofractional approach to the prostate cancer, if both LQ and LQL models were taken into consideration. Base on the finding, we established and conducted a pilot clininal study for the evaluation of the safty of hypofractional stereotactic intensity-modulated radiation therapy (C751). As of the end of March 2015, 17 cases out of 25 patients required in this study had been registered.

Free Research Field

放射線腫瘍学