Study of radiation responses via tumor-normal cell interaction

2015 Fiscal Year Final Research Report

• Project/Area Number: 24591857
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: National Institute of Radiological Sciences
• Principal Investigator: Shimokawa Takashi 国立研究開発法人放射線医学総合研究所, 重粒子医科学センター, チームリーダー (20608137)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 細胞間相互作用 / 放射線 / がん細胞 / 正常細胞

Outline of Final Research Achievements

This project aimed to clarify impact of microenvironment, especially interaction between cancer cells and stromal cells (normal cells), on radiation response of cancer cells. By using culture cells and mouse models, we showed that presence of normal cells surround of cancer cells significantly influenced radiation response of cancer cells. In addition, it has been shown that Wnt and Hedgehog signal pathways contribute greatly to radiation effects of cancer cells during the process. We had presented our findings at international conferences. A part of results was published in an international journal, and others have been in submission to international journals.

Free Research Field

放射線生物学