Clinical application of inhibition of Nuclear Factor-kappa B: oncogenic proliferation and surgical stress

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591870
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General surgery
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: OCHIAI Takanori 東京医科歯科大学, 医学部附属病院, 助教 (20447486)
• Co-Investigator(Kenkyū-buntansha): INOUE Yoshinori 東京医科歯科大学, 医歯(薬)学総合研究科, 講師 (70280964) ; SAITO Yasunori 東京医科歯科大学, 医歯(薬)学総合研究科, 助教 (00516312) ; YAMAOKA Shoji 東京医科歯科大学, 医歯(薬)学総合研究科, 教授 (50197513) ; TANAKA Shinji 東京医科歯科大学, 医歯(薬)学総合研究科, 教授 (30253420) ; TANABE Minoru 東京医科歯科大学, 医歯(薬)学総合研究科, 教授 (50197513)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: NF-κB / 癌 / 手術 / シグナル伝達

Outline of Final Research Achievements

Nuclear Factor-kappa B is activated by carcinogens, tumor promoters, inflammatory cytokines, and chemotherapeutic agents. We focused on anti-tumorigenesis and anti-inflammation effects by means of inhibition of NF-κB activity. ①We revealed that (1)molecular target agent (IMD-0354) suppressed constitutive NF-κB activity, (2)gemcitabine stimulated NF-κB activity, and (3)combined therapy of IMD-0354 and gemcitabine revealed enhanced anti-tumor effects. ②We investigated a swine model to assess the invasiveness of surgical stress. In this model, inferior vena cava, aorta, the trunks of celiac artery and superior mesenteric artery were exposed. Intraoperative hemodynamics were monitored at the stable points after clamping each vessels, respectively. Inhibition of NF-κB activity in this model is still ongoing.

Free Research Field

外科