2014 Fiscal Year Final Research Report
The analysis of immunological status against ABO blood type antigens after ABO incompatible liver transplantation
| Project/Area Number |
24591879
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Kyoto University |
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Principal Investigator |
YOSHIZAWA Atsushi 京都大学, 医学(系)研究科(研究院), 助教 (60457984)
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| Research Collaborator |
UEDA Daisuke 京都大学, 大学院医学研究科
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 移植免疫 / 肝移植 / 抗体 |
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| Outline of Final Research Achievements |
The aim of this project is to prove that immunological response against blood groups antigens has decreased after ABO-incompatible (ABO-i) liver transplantation. We analyzed this phenomenon in the aspect of clinical findings and in-vitro examination.
Throgh the clinical findings, we have found that antibody titers against ABO antigens significantly decreased after ABO-i liver transplantation. We analyzed the re-transplantation across ABO-i cases and found that the decrease of antibody titier was not the result of absorption of antibodies in allograft liver but the result of immunological unresponsiveness against ABO blood group antigens.To prove the immunological unresponsiveness, the response of PBMC, peripheral blood mononuclear cells from the ABO-i liver transplant recipients was examined. The response was examined through immune-deficient mice. The result shows that PBMC from ABO-i liver transplant recipients have lost the responsibility against ABO blood type antigens.
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| Free Research Field |
肝移植
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