Induction of tumor-specific memory cells in gastrointestinal cancer

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591887
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General surgery
• Research Institution: Nara Medical University
• Principal Investigator: SHO MASAYUKI 奈良県立医科大学, 医学部, 准教授 (50364063)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 腫瘍免疫 / 消化器癌 / T細胞

Outline of Final Research Achievements

In this study, we have evaluated several new molecules targeting T cell negative pathways in tumor immunity. As a result, we found that several molecules, including ETBR, HVEM CD155, and Nectin-4, play important roles in patient prognosis and postoperative recurrence in some human gastrointestinal malignancies such as esophageal, colorectal, hepatocellular carcinoma, and pancreatic cancer. In addition, in animal model, simultaneous blockade of PD-1 and anti-angiogenesis induced a synergistic in-vivo anti-tumour effect. This unique therapeutic strategy may hold significant promise for future clinical application.Our findings suggested that such molecules might have therapeutic potentials through the induction of tumor-specific memory T cells.

Free Research Field

医歯薬学