2014 Fiscal Year Final Research Report
Functional analysis of splicing variants of multidrug-resitant ABC transporters expressed in gastrointestinal cancer
| Project/Area Number |
24591895
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
General surgery
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MIURA Koh 宮城県立がんセンター, がん薬物療法研究部, 特別研究員 (40282074)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | ABCトランスポーター / 大腸癌 / 多剤耐性 |
|---|
| Outline of Final Research Achievements |
Bioinformatics analysis showed that seventy-one out of total 502 splicing variants of ABC transporters, which are registered in Ensembl, were detected as candidates of potential colon-cancer-specific-splice-variants.
Experimental validations were performed for some of these candidates by RT-qPCR. ENST000005135112, one of ABCA12 splice variants, had reproducibility. This result strongly suggests that ENST000005135112 is a colon-cancer-specific-splice-variant.
|
| Free Research Field |
大腸癌の集学的治療・分子生物学
|
