2014 Fiscal Year Final Research Report
Collagen Type V a3 chain applied new therapy for their anti-organ adhesion activity
| Project/Area Number |
24591918
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Tokai University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
INAGAKI Yutaka 東海大学, 医学部, 教授 (80193548)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 癒着防止 / V型コラーゲンα３鎖 / 組織線維化 |
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| Outline of Final Research Achievements |
Previously we found, collagen Type V α3(following α3(V)) is shown to have anti-fibrosis and tissue adhesion inhibition. Their included in an amnion slightly. The aim of this study that, purify from amnion and is to develop novel anti-adhesion devices by utilizing α3(V). However we have any difficulties for extraction of entire α3(V) molecule with kept functions. It was shown that partial α3(V) functional domain is used for more realistic approach in this aims. On the other hand, we have isolated and characterized by muscular fasciae derived cells that, expressed α3(V) and contributed anti-adhesion effect. Additionally, we construct several prototype devices with collagen base for tissue regeneration, in this study.
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| Free Research Field |
医歯薬学
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