Possibility of menin as a predictive factor for aromatase inhibitors

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591927
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General surgery
• Research Institution: The Tazuke Kofukai
• Principal Investigator: YAMAUCHI Akira 公益財団法人田附興風会, 医学研究所 第1研究部, 部長 (00291427)
• Co-Investigator(Kenkyū-buntansha): UENO Takayuki 杏林大学, 医学部, 講師 (40452362)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: メニン / 乳癌 / ホルモン療法 / アロマターゼ阻害剤

Outline of Final Research Achievements

We investigate the possibility of menin, a gene product of men1, as a negative predictive factor for the efficacy of aromatase inhibitors. We already clarified that menin enhances the transcriptional activity of estrogen receptors (ER) by physical association to ER, and investigate the association with clinical events. In this study, we finished to evaluate menin expression on breast cancer tissue. We have only to analyze the relationship between menin expression and clinical events, after clinical data come to be available.
Dr. Takafumi Ueno, a collaborator, demonstrated the negative correlation between menin expression and apoptosis assessed by TUNEL method. This suggests the possibility of menin as a negative predictive factor for the efficacy of aromatase inhibitors.

Free Research Field

乳腺外科学