2014 Fiscal Year Final Research Report
Phosphatome - targeted therapy for breast cancer
| Project/Area Number |
24591928
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
General surgery
|
|---|
| Research Institution | Miyagi Prefectural Hospital Organization Miyagi Cancer Center |
|---|
Principal Investigator |
KAKUGAWA YOICHIRO 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 特任研究員 (60221173)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
FUKAMACHI Kayoko 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 特任研究員 (00626137)
SHIMA Hiroshi 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 部長 (10196462)
NISHINO Yoshikazu 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん疫学・予防研究部, 部長 (70302099)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | 乳がん / HER2 / ホスファターゼ / PP6 / ノックアウトマウス / BRCA1 / SNPs |
|---|
| Outline of Final Research Achievements |
BRCA1 gene is identified as one of anti-cancer gene against breast cancer. The function of BRCA1 is regulated by its status of phosphorylation, and PP6 is thought to be involved in this regulation. In this experiment, we firstly showed that PP6 functions as anti-oncogene in vivo.
|
| Free Research Field |
医歯薬学
|
