2014 Fiscal Year Final Research Report
Development of the anti-HER3 antibody therapy for esophageal squamous cell carcinoma.
| Project/Area Number |
24591936
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
|
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| Research Institution | University of Yamanashi |
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Principal Investigator |
|
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| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | 食道扁平上皮癌 / 抗体療法 / HER3 |
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| Outline of Final Research Achievements |
Relations on expressions among HER family (HER1, HER2, HER3) and antitumor effect of anti-HER3 antibody against different HER3-expressed cell clones of esophageal squamous cell carcinoma were investigated. We found HER3 expressions did not correlated with powers of antiproliferative activity, ADCC or proapototic activity induced by anti-HER3 antibody in any cell clones. In addition, correlation between HER1/HER2 and HER3 expressions was not found.
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| Free Research Field |
癌免疫学
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