The role of cancer-related exosome on chemoresistance in esophageal cancer

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591942
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Research Institute, Osaka Medical Center for Cancer and Cardiovascular Disaeses (2014); Osaka University (2012-2013)
• Principal Investigator: MIYATA Hiroshi 地方独立行政法人大阪府立病院機構大阪府立成人病センター(研究所), その他部局等, その他 (80362713)
• Co-Investigator(Kenkyū-buntansha): SUGIMURA Keijiro 大阪府立成人病センター, 消化器外科, 医長 (00571374) ; YAMASAKI Makoto 大阪大学, 大学院消化器外科, 助教 (50444518) ; TAKAHASHI Tsuyoshi 大阪大学, 大学院消化器外科, 助教 (50452389) ; TANAKA Koji 大阪大学, 医学部附属病院 (70621019)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: エクソソーム / マイクロRNA / 食道癌 / 化学療法

Outline of Final Research Achievements

Our results suggested that miR-27 is involved in resistance to chemotherapy in esophageal cancer, through miR-27 -induced transformation of normal fibroblast into cancer-associated fibroblasts(CAFs), and that TGF-β　secreted from these CAF-like fibroblasts induces chemoresistance to cisplatin in esophageal cancer. Based on these results, we believe that miR-27 , which can be secreted from esophageal cancer with being contained in exosome, is a potential therapeutic target for esophageal cancer treated with anticancer drugs.

Free Research Field

腫瘍学