Experimental analysis of the factors which predict the prognosis and the efficacy of preoperative systemic chemotherapy with taxane for esophageal cancer

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591945
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: The University of Tokushima
• Principal Investigator: TANGOKU Akira 徳島大学, ヘルスバイオサイエンス研究部, 教授 (10197593)
• Co-Investigator(Kenkyū-buntansha): IMOTO Issei 徳島大学, 大学院ヘルスバイオサイエンス研究部, 教授 (30258610) ; KAWAKAMI Yukikiyo 徳島大学, 病院, 特任講師 (00596249) ; YOSHIDA Takahiro 徳島大学, 病院, 助教 (00380105) ; FURUKITA Yoshihito 徳島大学, 大学院ヘルスバイオサイエンス研究部, 助教 (20563810) ; NISHINO Takeshi 徳島大学, 病院, 医員 (80645193) ; YAMAMOTO Yota 徳島大学, 病院, 助教 (50522273) ; GOTO Masakazu 徳島大学, 病院, 特任助教 (00437659)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 食道癌 / 抗癌剤 / タキサン / 術前化学療法 / 抗癌剤感受性

Outline of Final Research Achievements

The expression of ALDH1, CXCL12, CXCR4 and CXCR7 in the specimens from esophageal cancer were evaluated by immunohistochemistry and RT-PCR. These results were compared with the clinicopathological parameters and survival of the patients.
Results: High expression of CXCR4 with cytoplasmic and nuclear staining and CXCR7 were associated with cause-specific survival (CSS). The expression levels of messenger RNA (mRNA) of CXCR4 and CXCR7 were significantly increased in the tumor tissue compared with the normal esophageal tissue analysed by RT-PCR. The expression levels of mRNAs of CXCR4 was associated with CSS, and the expression levels of mRNA of CXCL12 and CXCR4 were associated with recurrence-free survival.
ALDH1 was associated with postoperative recurrence and prognosis. CD44 was found to be associated with postoperative recurrence and prognosis after chemotherapy. ALDH1-negative groups displayed better prognoses with operation only. ALDH1 did not influence on the effect of chemotherapy.

Free Research Field

医歯薬学