Molecular target therapy induced by hypoxia for scirrhous gastric cancer.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591947
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Saga University
• Principal Investigator: KOGA Yasuo 佐賀大学, 医学部, 講師 (30555090)
• Co-Investigator(Kenkyū-buntansha): NAKAMURA Jun 佐賀大学, 医学部医学科, 助教 (60404175)
• Co-Investigator(Renkei-kenkyūsha): KITAJIMA Yoshihiko 佐賀大学, 医学部医学科, 助教 (30234256) ; MIYAKE Shusuke 佐賀大学, 医学部医学科, 助教 (70726893)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 胃癌 / 腹膜播種 / 低酸素

Outline of Final Research Achievements

The aim of the study was to clarify the role of hypoxia inducible factor (HIF)-1α in the development of peritoneal dissemination of gastric cancer. HIF-1α knockdown (KD) cells were established in the scirrhous gastric cancer cell line 58As9. Using KD and control (SC) cells, the presence of peritoneal dissemination was assessed in orthotopic implantation (o.i.) and intraperitoneal injection (i.p.) models. In the o.i. model, peritoneal dissemination was more frequently observed in the SC mice compared to the KD mice. In the i.p. model, a greater number of disseminated nodules was observed in the KD mice. Angiogenesis and vascular invasion were more aggressive in the SC gastric tumors. We provide a possible mechanism in which peritoneal dissemination of gastric cancer develops via a vascular network whereby HIF-1α activates tumor angiogenesis.

Free Research Field

消化器外科