The novel markers to predict the sensitivity to chemotherapy in ESCC and GC

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591949
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Kumamoto University
• Principal Investigator: SAITO seiya 熊本大学, 医学部附属病院, 非常勤診療医師 (00594475)
• Co-Investigator(Kenkyū-buntansha): HAYASHI Naoko 熊本大学, 医学部附属病院, 非常勤診療医師 (20452899) ; BABA Yoshifumi 熊本大学, 大学院生命科学研究部, 講師 (20599708) ; IWATSUKI Masaaki 熊本大学, 医学部附属病院, 非常勤診療医師 (50452777)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: microRNA 2 / RPN2 / chemo-resistance / PTEN / FBXW7

Outline of Final Research Achievements

We revealed that RPN2 expression in biopsy specimens could be a useful predictive marker for docetaxel-based neoadjuvant chemotherapy in ESCC. However, RPN2 expression is not associated microRNA expression. And therefore, we would reveal the relationship between Herceptin resistance and microRNA expression in gastric cancer. We revealed that the miR-21/PTEN pathway regulated the sensitivity of HER2-positive GC cell lines to trastuzumab through modulation apoptosis. Furthermore, we revealed the miR-223/FBXW7 pathway regulates the sensitivity of a HER2-positive GC cell line to trastuzumab through the modulation of apoptosis. We disclosed the miR-21/PTEN and miR-223/FBXW7 regulated the sensitivity of HER2-positive GC cell lines to trastuzumab through modulation apoptosis. We consider that miR-21 and miR-223 expression could be a useful predictive marker for Herceptin chemotherapy in gastric cancer.

Free Research Field

消化器外科学