2014 Fiscal Year Final Research Report
Exploration of biological charactoristics of residual cancer after chemotherapy
| Project/Area Number |
24591955
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kagoshima University |
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Principal Investigator |
ISHIGAMI SUMIYA 鹿児島大学, 医歯(薬)学総合研究科, 准教授 (90325803)
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| Co-Investigator(Kenkyū-buntansha) |
MAEMURA Kousei 鹿児島大学, 医歯学総合研究科, 特任准教授 (30398292)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 化学療法 / 消化器癌 / 遺残 / キャラクター |
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| Outline of Final Research Achievements |
We tried to investigate analysis of characteristics of residual cancer after the chemotherapy especially in gastrointestinal cancer.We previously demostrated the clinical significance of CD133 expression in gastric cancer including an independent prognostic factor. However, immunohistochemically, CD133 expression of the residual cancer after the chemotherapy could not reflect aggressiveness of tumor behavior in gastric cancer. We now tried to clarify the clinical significance of MIB-1, Fox3p positive cells, PDL1 expression in the cancer stroma after the chemotherapy.
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| Free Research Field |
医歯薬学
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