2014 Fiscal Year Final Research Report
Development of new diagnosis and treatment procedures based on chemokine network for esophageal cancer
| Project/Area Number |
24591960
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 食道扁平上皮癌 / ケモカイン / CXCL12 / CXCR4 / CXCL8 / CXCR2 |
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| Outline of Final Research Achievements |
In this study, we demonstrated that a positive CXCL12 expression correlates significantly with a lower recurrence-free survival rate in our esophageal squamous cell carcinoma (ESCC) patient population. These results suggest that CXCL12 expression in ESCC promotes the proliferation of the tumour and has a direct impact on the recurrence rate independently of invasion or metastasis. Furthermore, the fact that both CXCL12 overexpression and CXCL12 exposure similarly promote proliferation denotes that ESCC cells expressing CXCL12 secrete this factor and cell proliferation is stimulated by the binding of CXCL12 to CXCR4 on the cell membrane, via autocrine growth.
Increased expression of both CXCL-8 and CXCR-2 correlated with tumor progression, metastasis, higher preoperative levels of proinflammatory cytokines, CRP, activation of exogenous coagulation factors, and poor prognosis in ESCC patients.
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| Free Research Field |
消化器外科学
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