Extended indication of conversion hepatectomy for initially unresectable colorectal liver metastasis

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591990
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Hirosaki University
• Principal Investigator: HAKAMADA Kenichi 弘前大学, 医学(系)研究科(研究院), 教授 (30271802)
• Co-Investigator(Kenkyū-buntansha): ISHIDO Keinosuke 弘前大学, 医学部附属病院, 講師 (00436023) ; KUDO Daisuke 弘前大学, 医学部附属病院, 講師 (00587024) ; TOYOKI Yoshikazu 弘前大学, 大学院医学研究科, 准教授 (70301025)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 大腸癌肝転移 / 化学療法後肝切除 / 化学療法後肝障害 / イリノテカン / 脂肪肝炎 / 脂肪肝

Outline of Final Research Achievements

First, we successfully established a new model of chemotherapy-associated liver damage by treating rats with irinotecan, and found that genetic up-regulation of both cholesterol and fatty acid synthesis occurred prior to pathological fatty degeneration.Second, we introduced a new statistical technique of ultrasound called acoustic structure quantification method to the diagnosis of fatty degeneration caused by chemotherapy. Finally, by integrating multi-modalities of diagnostic imaging and liver function tests, we successfully could improve the surgical results of conversion hepatectomy for initially unresectable colorectal liver metastases as high as 60% of 5 year survival after surgery.

Free Research Field

消化器外科学