2014 Fiscal Year Final Research Report
Molecular targeting therapy for colorectal liver metastasis
| Project/Area Number |
24592001
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 消化器外科 / 腫瘍外科 / 転移 |
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| Outline of Final Research Achievements |
We examined the function of h-prune, and the role of h-prune in colorectal liver metastasis.
h-prune knocked-down cells revealed lower motility, invasiveness and less frequent expression of epithelial-mesenchymal transition markers. In liver metastasis mouse model, mice injected with h-prune knocked-down cells have significantly more frequent liver metastasis than control mice. The overall survival rate was significantly lower in h-prune-positive cases than in h-prune-negative cases. Multivariate analysis showed that h-prune positivity was the only independent factor related to poor overall survival of patients after curative hepatectomy.These results indicate that h-prune has a critical role in the progression of colorectal liver metastases, and it may be considered a newly defined prognostic factor.
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| Free Research Field |
消化器外科
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