Significance of Mesothelin expression in gastrointestinal cancer and relation with cancer malignancy

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592017
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Hokkaido University
• Principal Investigator: KAMACHI Hirofumi 北海道大学, 大学病院, 講師 (60374237)
• Co-Investigator(Kenkyū-buntansha): KAMIYAMA Toshiya 北海道大学, 医学研究科, 准教授 (80322816) ; NISHIHARA Hiroshi 北海道大学, 医学研究科, 特任准教授 (50322805) ; OZAKI Michitaka 北海道大学, 保健科学研究院, 教授 (80256510)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: mesotherin / cancer

Outline of Final Research Achievements

We investigated the relationship of cancer malignancies and mesothelin expression in the gastrointestinal cancer. Mesothelin expression was examined by immunohistochemical staining of surgical specimens of pancreas cancer (n=66), bile duct cancer (n=61), gastric cancer (n=110), colorectal cancer (n=91), and IPNMs (n=37). We compared between clinicopathological parameter, prognosis and mesothelin expression intensity and location, respectively. In all carcinomas, high-level of mesothelin expression was correlated with poor patient outcome. Moreover, co-expression with CA125 was poor prognostic factor in pancreas cancer, and luminal mesothelin expression was also poor prognostic factor in gastric cancer and in bile duct cancer. In colorectal cancer, mesotholin expression was correlated with lymphatic invasion in vitro sutudy and clinicopathological findings.

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