Early DNA damage response in residual carcinoma in situ at ductal stumps and local recurrence in patients undergoing resection for extrahepatic cholangiocarcinoma

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592021
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Niigata University
• Principal Investigator: WAKAI Toshifumi 新潟大学, 医歯学系, 教授 (50372470)
• Co-Investigator(Kenkyū-buntansha): MATSUDA Yasunobu 新潟大学, 医歯学系, 准教授 (40334669) ; AJIOKA Yoichi 新潟大学, 医歯学系, 教授 (80222610) ; KOYAMA Yu 新潟大学, 医歯学系, 教授 (10323966) ; NAGAHASHI Masayuki 新潟大学, 医歯学系, 助教 (30743918)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 早期DNA損傷修復機構 / 胆管癌 / 表層拡大進展 / p53-binding protein 1 / field carcinogenesis

Outline of Final Research Achievements

Clinically evident local recurrence of residual carcinoma in situ at ductal stumps is closely associated with 53BP1 inactivation and decreased apoptosis. In contrast, apoptosis associated with early 53BP1-mediated DNA damage response is one of the molecular biological mechanisms that permit a small proportion of patients with residual carcinoma in situ at ductal stumps to survive in the long term with no evidence of local recurrence. Based on the Early DNA damage response, 50% of patients with formation of intraepithelial spread of invasive carcinoma, whereas 50% of patients with formation of field carcinogenesis. The formation of superficial intraepithelial spread results from both intraepithelial spread of invasive carcinoma and field carcinogenesis.

Free Research Field

消化器外科学