Change of cancer and pericancerous tissue induced by inflammation, IL-6/TGF-beta crosstalk, in biliary tract cancers.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592024
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Research Institute, Osaka Medical Center for Cancer and Cardiovascular Disaeses (2014); Osaka University (2012-2013)
• Principal Investigator: KOBAYASHI Shogo 地方独立行政法人大阪府立病院機構大阪府立成人病センター(研究所), その他部局等, その他 (30452436)
• Co-Investigator(Kenkyū-buntansha): WADA Hiroshi 大阪大学, 医学系研究科, 助教 (00572554) ; NAGANO Hiroaki 山口大学, 医学系研究科, 教授 (10294050) ; MARUBASHI Shigeru 大阪大学, 医学系研究科, 助教 (20362725) ; KAWAMOTO Koichi 大阪大学, 医学系研究科, 助教 (30432470) ; EGUCHI Hidetoshi 大阪大学, 医学系研究科, 助教 (90542118)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 胆道癌 / 炎症性サイトカイン / 化学療法抵抗性 / 癌間質

Outline of Final Research Achievements

We revealed IL-6 / TGF-β crosstalk induced by inflammation in biliary tract cancers. This crosstalk induced Epithelial-Mesenchymal Transition (EMT) and chemo-resistance in cancer cells and invasion front of resected specimen, via SMAD4. There was possibility that this resistance might be removed by regulation of SMAD4 or Histone. Meanwhile, this resistance induced co-resistance for the other anti-cancer drugs via DNA repair system and population of stem cells; however, radiation therapy regulated this chemo-resistance. Taken together, chemo-resistance was noted at invasion front via inflammation (crosstalk) and chemo-radiation would be effective for this invasion front and it would be helpful for advanced surgical resection.

Free Research Field

肝胆膵移植外科