Development of cancer peptide vaccine for biliary tract cancer stem cells

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592041
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Tokyo Women's Medical University
• Principal Investigator: ARUGA Atsushi 東京女子医科大学, 医学部, 教授 (40221056)
• Research Collaborator: KARUBE Hiroyo ; KOBAYASHI Hajime ; KOGEN Yumi
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 癌ペプチドワクチン / 胆道癌 / 癌幹細胞 / 免疫療法 / 癌抗原

Outline of Final Research Achievements

Biliary tract cancer (BTC) is known as a poor-prognosis disease because it is difficult to diagnose in early stage and there are few effective treatments. Furthermore, it has been suggested that the treatment for cancer stem cell should be important to obtain the true efficacy in human cancer therapy. The object of this research is to identify cancer stem cell-specific antigens for the development of therapeutic cancer vaccine for biliary tract cancer. In this study, we could identify 6 antigens as biliary tract cancer stem cell-specific antigen candidates, LY6K, GPC3, WT1, WDR16, CDH3, and MUC1. It is expected that this results will bring a bright future to develop the therapeutic cancer vaccine for biliary tract cancer.

Free Research Field

腫瘍免疫