Experimental study on the risks of mal-pefusion in contemporary pediatric cardio-pulmonary bypass system

2015 Fiscal Year Final Research Report

• Project/Area Number: 24592053
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: University of Yamanashi
• Principal Investigator: SUZUKI Shoji 山梨大学, 総合研究部, 准教授 (30235949)
• Co-Investigator(Kenkyū-buntansha): KAGA Shigeaki 山梨大学, 総合研究部, 助教 (10422693) ; MATSUMOTO Masahiko 山梨大学, 総合研究部, 教授 (30372501) ; SAKAKIBARA Kenji 山梨大学, 総合研究部, 助教 (40419338)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 小児用人工心肺 / 潅流障害 / 充填液アルカリ化

Outline of Final Research Achievements

Mal-perfusion in contemporary pediatric cardio-pulmonary bypass (CPB) system has been occasionally found. We focused on alkalization of the priming solution induced by usual priming procedures which may lead to unexpected haemagglutination. By using recirculating circuit with a membrane oxygenator, hydrogen power (pH) of the various priming solutions, which were Lactate Ringer, Acetate Ringer, Bicarbonate Ringer, Hemodyalisate, and the various oxygenators, which were CX-FX05RW, HPO-06H-C, JK-JMOXIAIC06, D100-50534, ME62050061, BIOCUBEC2000, were studied.
The results concluded that any combinations of the solutions and equipment may lead to excessive alkalization of the priming solution which may be one of the factors of mal-perfusion. In particular, gas insufflation during priming accelerates and increases the risks. Reconsideration of the priming procedures for pediatric CPB is highly recommended.

Free Research Field

心臓血管外科