2014 Fiscal Year Final Research Report
The research of right ventricular dysfunction caused by pulmonary regurgitation
Project/Area Number |
24592059
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Thoracic surgery
|
Research Institution | Kyoto University |
Principal Investigator |
NAKATA TOMOHIRO 京都大学, 医学(系)研究科(研究院), 助教 (00559685)
|
Co-Investigator(Kenkyū-buntansha) |
IKEDA Tadashi 京都大学, 大学院医学研究科, 准教授 (40281092)
MIWA Senri 京都大学, 大学院医学研究科, 講師 (10359812)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Keywords | 右心不全 / 肺動脈弁閉鎖不全 / 動物モデル |
Outline of Final Research Achievements |
The evaluation of right ventricular function is not fully established because of the anatomical complexity of the right ventricle. The aims of the present study are to establish an animal model of pulmonary regurgitation and to clarify the relationship between functional and histological changes of the right ventricle. We succeeded to induce significant pulmonary regurgitation in canine model by placing some stitches from outside of pulmonary root to fix the pulmonary valve. After 3 months of observation, significant right ventricular dilatation developed, whereas no significant changes were observed in histological examination. Although additional study with longer observation period is necessary, this animal model could be used in investigating therapeutic approaches to treat chronic right ventricular dysfunction
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Free Research Field |
外科学
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