The development of novel therapeutic strategy for pediatric heart failure patients using ventricular assist devices and cardiac regnerative therapy.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592061
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: Osaka University
• Principal Investigator: UENO Takayoshi 大阪大学, 医学(系)研究科(研究院), 寄附講座准教授 (60437316)
• Co-Investigator(Kenkyū-buntansha): MIYAGAWA Shigeru 大阪大学, 大学院医学系研究科, 特任准教授(常勤) (70544237) ; IDE Haruki 大阪大学, 大学院医学系研究科, 特任助教 (90600122)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 再生医療 / 小児心不全 / 幹細胞治療

Outline of Final Research Achievements

To establish novel therapeutic strategy for pediatric severe heart failure, we have completed pre-clinical studies regarding cardiac regenerative therapy. We have proved the safety and feasibility of novel synthetic prostacyclin agonist therapy for DCM rat and juvenile autologous skeletal muscle stem cell therapy for young ICM animal model. Those results implied the stem cell therapy for young patients will have greater therapeutic potentials than adult patients. We experienced a case of myoblast sheet implantation for DCM pediatric patient. No severe adverse events were found and her cardiac function and performance status improved during follow up period. Now we have been preparing for PI initiated clinical trial for approval to expand indication of the therapeutic strategy to pediatric heart failure patients.

Free Research Field

小児心臓血管外科