Novel therapeutic strategy for heart failure focusing on mechanical stress

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592067
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: Yamaguchi University
• Principal Investigator: SHIRASAWA Bungo 山口大学, 医学(系)研究科(研究院), 准教授 (80444719)
• Co-Investigator(Kenkyū-buntansha): HAMANO Kimikazu 山口大学, 大学院医学系研究科, 教授 (60263787) ; LI Tao-Sheng 長崎大学, 原爆後障害医療研究所, 教授 (50379997)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: メカニカルストレス / 進展刺激 / 心筋幹細胞 / 細胞移植治療

Outline of Final Research Achievements

In this study, we examined whether mechanical stress affects a behavior of cardiac stem cells (CSCs), because of the fact that higher transplantation efficiency in heart failure patients with a left ventricular assist device. Cell viabilities and proliferation capacity were significantly decreased in stretch-induced human CSCs, while production of angiogenic factors were up-regulated. In addition, transplantation of CSCs into infarcted heart of haemodynamic unloading mouse models showed an increase of transplantation efficiency, resulting in heart regeneration. Taken together, our results indicate that inhibition of mechanical stress might improve an efficiency of cell-based therapy for severe heart failure.

Free Research Field

心臓血管外科