2014 Fiscal Year Final Research Report
Creation of transplant heart with decellulalized heart and mesenchymal stem cell
| Project/Area Number |
24592072
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OKAMOTO Kazuma 慶應義塾大学, 医学部, 講師 (10338064)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 脱細胞化 / 再細胞化 / 異所性移植 |
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| Outline of Final Research Achievements |
At present, the only treatment for severe heart failure is heart transplantation. However, shortage of donor heart has raised a long waiting list and limited its benefit. As an alternative of heart transplantation, regeneration of heart with organ decellularization technique has been applied. Our ultimate goal is to create a whole beating heart fabricated based on an organ scaffold for human heart transplantation.
A porcine heart was harvested and decellularized by perfusion. The whole-heart scaffold was transplanted in a pig by surgical anastomosis using vessel grafts. The transplanted heart scaffold was harvested on day three after transplantation. Histological report showed that blood clot was accumulated in coronary artery. However, blood perfusion was maintained through left to right intra-cardiac shunt.
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| Free Research Field |
心臓血管外科
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