Lung protection in cardiac surgery with cardiopulmonary bypass: effect of low frequency ventilation during cardiopulmonary bypass in clinical practice

2015 Fiscal Year Final Research Report

• Project/Area Number: 24592076
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: Nippon Medical School
• Principal Investigator: IMURA HAJIME 日本医科大学, 医学部, 病院教授 (40281422)
• Co-Investigator(Renkei-kenkyūsha): YOSHIO TAKAHIDE 日本医科大学, 医学部, 助教 (60591287) ; TAKAHASHI KENICHIRO 日本医科大学, 医学部, 助教 (10614737)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 人工心肺 / 肺障害 / サイトカイン / 虚血再灌流 / 気管支液

Outline of Final Research Achievements

This study investigated whether low frequency ventilation (LFV) would improve lung in-jury due to cardiopulmonary bypass (CPB) in patients who underwent cardiac surgeries. Patients in LFV group showed significantly higher PaO2 at 2 hours after CPB and PaC-O2 was significantly lower immediately after CPB. LFV group also showed significantly lower lactate leakage from the lungs after 2 hours from stopping CPB, which suggested that LFV would reduce ischemia-reperfusion injury during and after CPB. In analysis of cytokines in bronchial smear fluid, LFV group showed significantly lower IL-6 and IL-8 than control group and thus, suppression of inflammatory response by LFV was also indicated. Since ventilation time tended to be shorter in LFV group than in control group, it is supposed that LFV can provide clinical benefit to patients of cardiac sureries.

Free Research Field

心臓血管外科