2014 Fiscal Year Final Research Report
Anti-tumor effector mechanisms of activated NKT cells in the tumor microenvironment for novel NKT cell-based immunotherapy
| Project/Area Number |
24592083
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Chiba University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 免疫学 / NKT細胞 / 免疫療法 / バイオマーカー |
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| Outline of Final Research Achievements |
We investigated the cellular and molecular mechanisms underlying potent anti-tumor effects of ligand activated invariant NKT cells. We established the lung cancer treatment models using severe combined immunodeficiency mouse and found out that activated iNKT cells augmented the cytotoxicity of tumor-antigen specific CD8+ T cells in vitro and in vivo. The number of CD8+ T cells and interferon-gamma production in the tumor microenvironment were increased after combination immunotherapy with CD8+ T cells and iNKT cells.
Ltb4dh gene was up-regulated in good responder cases after iNKT cell-based immunotherapy. We demonstrated that increased ltb4dh expression could overcome the tumor-derived immune suppressive effects. Therefore, it raises the possibility that the regulation of this gene could lead to the improvement of therapeutic effect of iNKT cell-based immunotherapy.
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| Free Research Field |
NKT細胞による抗腫瘍効果発揮機序の解明およびNKT細胞を利用した免疫細胞療法の開発研究
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