Genetic backgrounds associated with multicentric developmant of lung adenocarcinoma

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592096
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: Kumamoto University
• Principal Investigator: IKEDA KOEI 熊本大学, 医学部附属病院, 助教 (20448525)
• Co-Investigator(Kenkyū-buntansha): SUZUKI Makoto 熊本大学, 大学院生命科学研究部, 教授 (80312940) ; SHIRAISHI Kenji 熊本大学, 大学院生命科学研究部, 助教 (70363538)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 多発肺腺癌 / メチル化 / アロマターゼ / エストロゲン / CYP19A1

Outline of Final Research Achievements

A minor allele of SNP rs3764221, which is located in the CYP19A1 gene, was significantly associated with multiple adenocarcinomas risk. Other analyzed polymorphisms and LINE-1 methylation level of normal lung tissue were not significantly associated with the risk of multiple adenocarcinomas.
Conclusions: A minor allele of SNP rs3764221, which is located in the CYP19A1 gene, was significantly associated with multiple adenocarcinomas risk. Other polymorphisms and LINE-1 methylation levels of background lung were not significantly associated with the risk of multiple adenocarcinomas.

Free Research Field

呼吸器外科学