Involvement of E-selectin in reimplantation lung injury

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592100
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: Keio University
• Principal Investigator: GOTO Taichiro 慶應義塾大学, 医学部, 共同研究員 (80317148)
• Co-Investigator(Kenkyū-buntansha): OHTSUKA Takashi 慶應義塾大学, 医学部, 講師 (40306717) ; OKUI Masayuki 慶應義塾大学, 医学部, 助教 (30594494) ; TAKAHASHI Yusuke 帝京大学, 医学部, 助教 (00445214) ; ANRAKU Masaki 東京大学, 医学部附属病院, 助教 (70598557)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 肺移植 / 急性肺損傷 / セレクチン / 好中球 / 動物モデル

Outline of Final Research Achievements

Reimplantation lung injury is a major complication after the lung transplantation and remains yet to be solved. In this study using rat transplantation model, soluble E-selectin was found to be correlated with the lung injury score, suggesting it to be a serum marker. In the chimeric rat transplantation models, lung transplantation using the E-selectin deficient rat as the donor, caused significantly less injury, suggesting that membranous E-selectin upregulation is the trigger of acute lung injury. Serum soluble E-selectin was increased only in case wildtype lung was utilized as the donor, which suggests, soluble E-selectin could be shed and released from the membranous E-selectin. In our new lung transplantaion models, which converted the blood flow from pulmonary vein to pulmonary artery, pulmonary fibrosis resembling the interstitial pulmonary fibrosis might appear mainly in the peripheral lungs.

Free Research Field

肺移植