2014 Fiscal Year Final Research Report
Metastatic mechanism of the lung adenocarcinoma: AQP1 overexpression by the HIF-1/ histone modification adjustment
| Project/Area Number |
24592106
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
UEDA Yoshimichi 金沢医科大学, 医学部, 教授 (50271375)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 肺癌 / AQP1 / HIF-1α / ヒストン修飾 |
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| Outline of Final Research Achievements |
About the expression mechanism of aquaporin (AQP)1 in lung adenocarcinoma invasion, we studied to the contribution of the gene expression adjustment mechanism of the epigenetics.H3K4me2 was associated with postoperative recurrence, but AQP1 / HIF-1α and histone modification, there was no association. Also, the histone ornamentation in the lung adenocarcinoma was not associated with the tumor marker. H3K4me2 was associated with the examination for FDG-PET and the cell growth factor. Although we were not found, as for the association of AQP1 and JMJD2B, AQP1 was enhanced under hypoxia, and it was suggested to go by way of EZH2 course as a enhancement process. The relations with LSD1 and AQP1 / EZH2 / HIF-1α were subobsolete.
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| Free Research Field |
呼吸器外科学
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