Prevention for formation and enlargement of cerebral aneurysm by polyphenol

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592111
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Hirosaki University
• Principal Investigator: OHKUMA Hiroki 弘前大学, 医学(系)研究科(研究院), 教授 (40211099)
• Co-Investigator(Kenkyū-buntansha): ASANO Kenichirou 弘前大学, 医学(系)研究科(研究院), 准教授 (90312496) ; SHIMAMURA Norihito 弘前大学, 医学(系)研究科(研究院), 講師 (40312491) ; MUNAKATA Akira 弘前大学, 医学部附属病院, 医員 (80400159)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 脳動脈瘤 / ポリフェノール

Outline of Final Research Achievements

The aim of this study was to investigate the efficacy of polyphenol for prevention of formation and/or enlargement of cerebral aneurysm. Cerebral aneurysm was induced by ligation of bilateral carotid artery in rabbit. In treatment group, 40mg/kg/day of apple polyphenol was orally administered. In non-treatment group, arterial wall became thin, the number of smooth muscle cells decreased, and cerebral aneurysm was seen in 75% rabbit 3 months after bilateral carotid artery ligation. In treatment group, these findings were suppressed, and aneurysm formation was seen in 13% rabbit. I order to investigate the preventative effect of polyphenol, apple polyphenol was administered for 3 months from 3 months after bilateral carotid artery ligation. The size of cerebral aneurysm in the treatment group was significantly smaller than the non-treatment group. These results suggest that polyphenol has preventative effects on formation and enlargement of cerebral aneurysm.

Free Research Field

脳神経外科