Arterial spin labeling MRI measurement is affected by water permeabilty change.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592115
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: TANAKA YOJI 東京医科歯科大学, 医学部附属病院, 講師 (80323682)
• Co-Investigator(Kenkyū-buntansha): NARIAI Tadashi 東京医科歯科大学, 大学院医師学総合研究科, 准教授 (00228090)
• Co-Investigator(Renkei-kenkyūsha): INAJI Motoki 東京医科歯科大学, 医学部附属病院, 講師 (00422486)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: MRI / arterial spin labeling / cerebral ischemia / blood brain barrier / water permeability / transit time

Outline of Final Research Achievements

Arterial spin labeling (ASL) MRI is a useful method to measure cerebral blood flow (CBF) non-invasively. However, the improvement of quantitativity of ASL is still needed. We evaluated the accuracy of ASL method by comparing with other modalities as positron CT and single photon emission CT. It was clarified that both transit delay and permeability change were the important factors that affected the ASL-CBF differently. Taking into account with these parameters will improve the accuracy of ASL-CBF measurement.

Free Research Field

脳神経外科学