2014 Fiscal Year Final Research Report
The neuronal protective and regenerative effects of glucagon-like peptide 1 agonist against transient forebrain ischemia
| Project/Area Number |
24592118
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | University of Yamanashi |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HORIKOSHI Tohru 山梨大学, 総合研究部, 医学研究員 (50209300)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 脳虚血 / 神経保護 / 神経再生 / アポトーシス / GLP-1 / exendrin-4 |
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| Outline of Final Research Achievements |
Elucidating the mechanisms of neuronal apoptosis and its prevention is crucial for the development of a new therapeutic strategy for stroke. Glucagon-like peptide 1 (GLP-1) agonist; exendrin-4 showed a tendency to decrease the amount of apoptosis cells in the CA1 region of the rat hippocampus after transient forebrain ischemia. In addition, the number of Ki67 positive cells tends to increase in the group injected exendrin-4. Thus, theses results suggest that exendrin-4 has neuroprotective effect and regulates neuronal regeneration under physiological and ischemic conditions.
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| Free Research Field |
脳神経外科
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