Development of gellan sulfate core platinum coil with bioactive substances

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592122
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Mie University
• Principal Investigator: MATSUSHIMA Satoshi 三重大学, 医学(系)研究科(研究院), リサーチアソシエイト (50252367)
• Research Collaborator: MIURA Yoichi 鈴鹿回生病院 (10420390) ; HAMADA Kazuhide 桑名西医療センター (00464165) ; TOMA Naoki 三重大学, 医学系研究科, 講師 (80362341) ; SUZUKI Hidenori 三重大学, 医学系研究科, 教授 (90345976)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 脳動脈瘤 / 脳血管内治療 / 生理活性 / コイル

Outline of Final Research Achievements

We conduct this study for the aim of evaluating the effects of Gellan sulfate core platinum coil (GSCC) with tenascin-C (TNC) (GSCC-TNC). Elastase-induced rabbit aneurysms were randomly coiled with platinum coils (PCs), GSCCs or GSCC-TNCs and aneurysm-occlusion status was evaluated at 2 weeks post-coiling. In addition, a PC, GSCC or GSCC-TNC was randomly implanted in a rat blind-ended model and the organization effects were immunohistochemically evaluated for expressions of TNC, transforming growth factor-beta (TGF-β) and matrix metalloproteinase-9 (MMP-9) 2 weeks later. As a result, GSCCs showed a significantly higher ratio of organized area to the aneurysmal cavity than PCs. GSCC-TNCs had intense immunoreactivities for TNC, TGF-β and MMP-9 in the organized thrombosis and tunica media.
GSCC-TNCs demonstrated potent aneurysm repair effects in a simulated clinical setting using rabbits possibly through the TGF-β and MMP-9 upregulation.

Free Research Field

医歯薬学