Water-free Na accumulation facilitates the formation of cerebral aneurysm through down-regulation of sodium excretion pump in ovariectomized rats

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592131
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: The University of Tokushima
• Principal Investigator: SATOMI Junichiro 徳島大学, ヘルスバイオサイエンス研究部, 准教授 (10304510)
• Co-Investigator(Kenkyū-buntansha): NAGAHIRO Shinji 徳島大学, 大学院ヘルスバイオサイエンス研究部, 教授 (60145315) ; TADA Yoshiteru 徳島大学, 大学院ヘルスバイオサイエンス研究部, 助教 (30547964) ; KANEMATSU Yasuhisa 徳島大学, 病院, 助教 (90363142)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 脳・神経 / 脳血管病 / エストロゲン / 高塩分摂取 / 高血圧

Outline of Final Research Achievements

Hypertension is thought to be associated with a high incidence of stroke. However, not all patients with unruptured cerebral aneurysms are hypertensive. We hypothesized that in oophorectomized rats fed a high salt diet (HSD), body water-free Na+ accumulation may be increased, leading to the formation of cerebral aneurysms. Compared to HSD rats, the incidence of cerebral aneurysms and the body Na+-to-water ratio were significantly higher in HSD/OVX- and HSD/OVX/renal hypertensive (RL) rats independent of hypertension. In their aneurysmal wall, ATP1α2, a subtype of Na+/K+-ATPase were down-regulated and renin-angiotensin system- and inflammation related molecules were up-regulated. A reduction in the vascular Na efflux pump in ovariectomized rats may be associated with the increase in water-free Na+ accumulation directing to cerebral aneurysm formation.

Free Research Field

脳神経外科学