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2014 Fiscal Year Final Research Report

Characteristic analysis of mesenchymal stem cells for regenerative medicine

Research Project

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Project/Area Number 24592138
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cerebral neurosurgery
Research InstitutionSapporo Medical University

Principal Investigator

RIE Onodera  札幌医科大学, 医学部, 講師 (60393328)

Co-Investigator(Kenkyū-buntansha) HONMOU Osamu  札幌医科大学, 医学部, 教授 (90285007)
WANIBUCHI Masahiko  札幌医科大学, 医学部, 准教授 (30343388)
SASAKI Masanori  札幌医科大学, 医学部, 講師 (20538136)
MIKAMI Takeshi  札幌医科大学, 医学部, 講師 (30372816)
KOBAYASHI Masaki  札幌医科大学, 医学部, 助教 (70592715)
NAKAZAKI Masahito  札幌医科大学, 医学部, 研究員 (70722461)
SAKAI Takurou  札幌医科大学, 医学部, 研究員 (80639229)
SASAKI Yuichi  札幌医科大学, 医学部, 研究員 (00570136)
SUZUKI Junpei  札幌医科大学, 医学部, 研究員 (00572596)
MORITA Tomonori  札幌医科大学, 医学部, 研究員 (60723343)
Project Period (FY) 2012-04-01 – 2015-03-31
Keywords骨髄間葉系幹細胞
Outline of Final Research Achievements

Recent advance in regenerative medicine have demonstrated that greater therapeutic efficacy can be obtained by stem cell therapy via multiple mechanisms compared to the standard therapies for various diseases. Especially, it has been suggested that bone marrow stem cells may represent an alternative source of neural progenitor cells for organ regeneration. Among bone marrow stem cells, much attention has been paid to mesenchymal stem cells (MSCs, also referred to as bone marrow stromal cells) because of their plasticity for differentiation into classical mesenchymal lineages, such as neuronal lineages. In this study, cell biological analyses were performed with MSCs from human and rat bone marrow using several molecular, biochemical and genetics approaches. Therapeutic efficacy with rat MSCs in vivo was also examined with rat stroke model.

Free Research Field

再生医療

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Published: 2016-06-03  

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