Japanese brain-database of sulcal and gyral patterns based on functional information contribute to clinical application

2015 Fiscal Year Final Research Report

• Project/Area Number: 24592146
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Tokyo Women's Medical University
• Principal Investigator: Tamura Manabu 東京女子医科大学, 医学部, 講師 (80453174)
• Co-Investigator(Renkei-kenkyūsha): Muragaki Yoshihiro 東京女子医科大学, 医学部, 教授 (70210028) ; Sakai Kuniyoshi 東京大学, 総合文化研究科, 教授 (10251216)
• Research Collaborator: Francois Mangin Jean Neurospin, Biomedical Imaging Institute, CEA
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: brain database / sulal and gyral patterns / diffusion tensor imaging / focal cortical dysplasia / dystonia

Outline of Final Research Achievements

We successfully analyzed high-field magnetic MR image to get labeled sulcal and gyral patterns of cerebral cortex on the three dimensional brain surface views, comparing with the description of intra-cranial diffusion tensor imaging and functional MRI. Based on this functional database comparing to a standard brain model, the structure in patients (especially suffering from focal cortical dysplasia and brain tumor) was analyzed. This study contributed greatly to clinical application aimed for the recovery from brain deterioration as well as a possibility of clarifying the process of the cortical formation.

Free Research Field

脳神経外科学、MRI画像解析、定位放射線外科