2015 Fiscal Year Final Research Report
The mechanisms of brain ischemic cell damage with type 2 diabetes and new therapeutic approaches.
| Project/Area Number |
24592147
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | International University of Health and Welfare (2014-2015)
Nippon Medical School (2012-2013) |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Keywords | 脳梗塞 / 糖尿病 / 骨髄単核球移植 / バルプロ酸 / 併用療法 / 虚血モデル |
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| Outline of Final Research Achievements |
We tried to explore the appropriate transient middle cerebral artery occlusion model with type 2 diabetic rats. We tried to compare the 90 min occlusion of middle cerebral artery, together with the common carotid artery for 15min, 30min, and 45 min, individually. Ninety min occlusion of middle artery occlusion with 15 min common carotid artery occlusion model was appeared to be best in our condition. We also explore the brain protective mechanisms of valpronic acid, and explored the combination effects with bone marrow mononuclear cell transplantation therapy, from the points of view of anti-apoptotic, anti-oxidative damage, and anti- inflammatory effects.
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| Free Research Field |
脳卒中学
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