The new neurogenesis imaging for the development of in vivo clinical applications

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592148
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Meiji University of Integrative Medicine
• Principal Investigator: HIGUCHI Toshihiro 明治国際医療大学, 医学教育研究センター, 教授 (80218700)
• Co-Investigator(Kenkyū-buntansha): TANAKA Chuzo 明治国際医療大学, 医学教育研究センター, 名誉教授 (80163541) ; UMEDA Masahiro 明治国際医療大学, 医学教育研究センター, 教授 (60223608) ; WATANABE Yasuharu 明治国際医療大学, 医学教育研究センター, 講師 (90454537) ; KAWAI Yuko 明治国際医療大学, 医学教育研究センター, 助教 (90555616)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: MRS / 代謝 / 内在性神経細胞 / 神経再生

Outline of Final Research Achievements

Proton magnetic resonance spectroscopy (1H-MRS) has been widely used for detection of metabolites that are specific for tissues and these compounds have been used as reliable biomarkers. The purpose of these studies is to detect the "neurogenesis imaging" technique using 1H-MRS signal, and propose the clinical application. The 1.28-ppm chemical shift correlates with neurogenesis and suggest that can be analyzed using the 1.28-ppm biomarker as a valid reference for NPCs. We found the NPCs specific spectra at 1.28ppm in the human brain using 3.0-T MRI.

Free Research Field

脳神経外科学