Convection-enhanced drug delivery into the spinal cord

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592151
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Tohoku University
• Principal Investigator: SHIN-ICHIRO Sugiyama 東北大学, 医学(系)研究科(研究院), 非常勤講師 (30623152)
• Co-Investigator(Kenkyū-buntansha): ENDO Toshiki 東北大学, 大学院医学系研究科, 助教 (00535370) ; FUNAMOTO Kenichi 東北大学, 流体科学研究所, 助教 (70451630)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: ドラッグ・デリバリー / コンピュータ・シミュレーション

Outline of Final Research Achievements

Convection-enhanced delivery (CED) is a method for distributing small and large molecules locally in the interstitial space of the spinal cord. Delivering these molecules to the spinal cord is otherwise difficult due to the blood-brain or spinal cord barrier. This study revealed regional distribution of macromolecules in the gray and white matter of the spinal cord. In addition, we developed computational methods to predict drug distribution after CED. Finally, we conducted CED treatment for patients with malignant spinal tumor under the approval of the ethical board in Tohoku University Hospital, and got excellent results.

Free Research Field

脳神経外科学