In vivo PET and optical imaging of neurogenesis of neuronal circuit

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592155
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: INAJI Motoki 東京医科歯科大学, 医学部附属病院, 講師 (00422486)
• Co-Investigator(Renkei-kenkyūsha): HIGUCHI Makoto 独立行政法人放射線医学総合研究所分子神経イメージンググループ, グループリーダー (10373359) ; MAEDA Jun 独立行政法人放射線医学総合研究所分子神経イメージンググループ, 主任研究員 (30415426) ; SATO Katsushige 駒沢女子大学, 人間健康学部, 教授 (80291342)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: PET / 光学計測

Outline of Final Research Achievements

1. Optical recording method have demonstrated the development of cortico-striatum circuit in the slice of the rat brain. It also showed the electro-physiolosical connection from transplanted cells in the slice of PD model rats. We also evaluated new voltage-sensitive fluorescence dyes for monitoring neuronal activity in the embryonic central nervous system.2. We demonstrated cell proliferation precisely in brain tumor patients using 11C-4DST-PET image. It can also visualize the neurogenesis of transplanted cells. 3.PET imaging of transplanted PD model rats showed the time course of expression of dopamine transporter and normalization of dopamine D2 receptors binding.

Free Research Field

脳神経外科