Development and pharmacological verification of a new mouse model of central post-stroke pain

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592166
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Kagoshima University
• Principal Investigator: ARITA Kazunori 鹿児島大学, 医歯(薬)学総合研究科, 教授 (90212646)
• Co-Investigator(Kenkyū-buntansha): TOKIMURA Hiroshi 鹿児島大学, 医歯(薬)学総合研究科, 准教授 (50227568) ; MIYATA Atsuro 鹿児島大学, 医歯(薬)学総合研究科, 教授 (60183969) ; KURIHARA Takashi 鹿児島大学, 医歯(薬)学総合研究科, 准教授 (60282745)
• Research Collaborator: HANADA Tomoko 鹿児島大学, 医学部・歯学部附属病院, 医員
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: アロディニア / 慢性疼痛 / 痛覚過敏 / 脳内出血 / ミクログリア / ミノサイクリン / 視床痛

Outline of Final Research Achievements

Central post-stroke pain (CPSP) including thalamic pain is one of the most troublesome sequelae that can occur after a cerebrovascular accident. CPSP is often treatment-refractory, painful sensations can be a major problem. To better understand of the pathophysiological basis of CPSP, we developed and characterized a new mouse model of thalamic it. This model is based on a hemorrhagic stroke lesion with collagenase in the ventral posterolateral nucleus of the thalamus. Histopathological analysis indicated that the thalamic hemorrhage produced a relatively confined lesion that destroys the tissue within the initial bleed, and also showed the presence of activated microglia adjacent to the core of hemorrhagic lesions. Behavioral analysis demonstrated using several drugs which effects were recognized clinically. These results suggest that this model might be proved as a useful animal model for studying the neuropathology of thalamic syndrome, and developing improved therapeutics for CPSP.

Free Research Field

脳神経外科学