Investigation for abnormal distribution of SV2A and disorder of synaptic vesicle release in refractory epilepsy

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592169
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Kagoshima University
• Principal Investigator: HANAYA Ryosuke 鹿児島大学, 医学部・歯学部附属病院, 講師 (60304424)
• Co-Investigator(Kenkyū-buntansha): YUNOUE Syunji 鹿児島大学, 医歯(薬)学総合研究科, 研究員 (20404478) ; SUGATA Sei 鹿児島大学, 医歯(薬)学総合研究科, 研究員 (70437961) ; ARITA Kazunori 鹿児島大学, 医歯(薬)学総合研究科, 教授 (90212646)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: てんかん原性 / シナプス小胞蛋白 / SVA2 / Synaptotagmin-1 / FDG-PET

Outline of Final Research Achievements

We immunohistochemically evaluated the role of synaptic vesicle protein, SV2A about the expression of epilepsy using specimens of surgically treated-patients. SV2A decreased in the wide area of the brain, and the decrease of synaptotagmin-1 localized around epilepsy focus, whereas SNARE-related protein disorder would participate in the formation of epileptogenicity. Hypometabolism of FDG-PET, which indicated brain dysfunction overlapped in the decease of SV2A. SV2A mediated synaptic vesicle-releasing mechanism would be disturbed in dysfunctional brain around epileptogenic area, it was suggested that.

Free Research Field

脳神経外科学、てんかん学、神経薬理学