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2014 Fiscal Year Final Research Report

Neuromodulation by SCS for poststroke pain

Research Project

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Project/Area Number 24592176
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cerebral neurosurgery
Research InstitutionNihon University

Principal Investigator

YAMAMOTO Takamitsu  日本大学, 医学部, 教授 (50158284)

Co-Investigator(Kenkyū-buntansha) FUKAYA Chikashi  日本大学, 医学部, 准教授 (50287637)
OSHIMA Hideki  日本大学, 医学部, 准教授 (20328735)
KOBAYASHI Kazutaka  日本大学, 医学部, 准教授 (20366579)
Project Period (FY) 2012-04-01 – 2015-03-31
Keywords脊髄刺激 / 脳卒中後疼痛 / ケタミン
Outline of Final Research Achievements

We have examined whether the pharmacological evaluation of central poststroke pain (CPSP) is useful to select the candidate of SCS therapy, and examined about the analgesic effects of dual-lead SCS in CPSP patients.
Changes in visual analog scale (VAS) score for pain following pharmacological evaluation using morphine, thiopental, and ketamine were compared with the long-term follow up results of dual-lead SCS. Effective pain reduction by dual-lead SCS in CPSP patients were obtained mainly in ketapine-sensitive cases. Among 27 ketamin-sensitive patients, chronic implantation was applied in 21 of 27 (77.7%) patients. The dual-lead SCS showed long-lasting pain reduction in 15 of 21 (71.4%) CPSP patients.
We conclude that pharmacological evaluation and dual-lead SCS are very important for the treatment of CPSP patients, and that ketamine-sensitive CPSP patients are good candidate for dual-lead SCS therapy.

Free Research Field

機能神経外科

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Published: 2016-06-03  

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