Identification of factors which induce radiation injury, and establishment of tailor-made irradiation based upon these factors.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592179
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Chiba Cancer Center (Research Institute)
• Principal Investigator: IUCHI TOSHIHIKO 千葉県がんセンター(研究所), 脳神経外科, 部長 (80370881)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 脳腫瘍学 / 放射線脳壊死

Outline of Final Research Achievements

The change in copy number, but not mutation, of PDGFRA was associated with radiation necrosis. We could not find other molecules which showed significant correlation with radiation necrosis, from the analyses by array-CGH, cDNA array, and next generation sequencing. On the other hand, the methylation status of MGMT gene promoter was significant risk factor for radiation injury, and tumors with methylated MGMT gene promoter had higher risk for necrosis. Tailor-made setting of irradiation doses (high-dose for MGMT unmethylated cases, and moderate-dose for methylated ones) had revealed that decrease of irradiation dose had contributed to prevent radiation injury, while keeping the same survival benefit of irradiation. These findings indicated the feasibility of tailor-made setting of treatment doses based upon the methylation status of MGMT gene promoter.

Free Research Field

医療薬学