Patho-mechanism and new diagnosis tool of low back and joint pain. Investigation of new treatment for low back and joint pain.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24592185
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Chiba University
• Principal Investigator: OHTORI Seiji 千葉大学, 医学(系)研究科(研究院), 講師 (40361430)
• Co-Investigator(Kenkyū-buntansha): TAKAHASHI Kazuhisa 千葉大学, 医学(系)研究科(研究院), 教授 (20179477) ; INOUE Gen 北里大学, 医学部, 准教授 (80594209)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 腰痛 / 関節痛

Outline of Final Research Achievements

We prospectively evaluated the effect of PRP on bone union in human posterolateral lumbar fusion (PLF) surgery. Thirty-nine patients undergoing 1- or 2-level instrumented PLF for lumbar degenerative spondylosis with instability were randomized to receive either PRP or control groups. All patients in both groups showed significant bone union at final follow-up. The average period for union was 7.8 months in the PRP group and 9.8 months in the control group (p < 0.05). The platelet count and growth factor concentrations in PRP were 7.7- and 50-times greater than those in plasma, respectively (p < 0.05).PRP-treated patients showed more rapid bone union after spinal fusion surgery than the control.

Free Research Field

脊椎外科